rumentas bolus is an antibiotic medicine specially medicated for dairy cattle and buffalo, rumentas bolus used under the treatment of bacterial infection like metritis, post partum septic metritis, pyometra, cervicitis, endometritis. NTP TOX 11 NIHPublication No. This research was supported by the National Basic Research Program of China [Grant 2012CB910401]; the National Natural Science Foundation of China [Grants 81101683, 81402482, 30930055, and 31271468]; the Science and Technology Commission of Shanghai Municipality [Grants 12XD1406100, 12ZR1408700, and 11DZ2260300]; the Chenguang Program from Shanghai Municipal Education Commission [Grant 10CG25]; and the Fundamental Research Funds for the Central Universities [Grant 78260029]. 229-436-1. In contrast, the minimum LD50s for potassium antimony tartrate were 11 and 15 mg Sb/kg bw after intraperitoneal injection. P273: Avoid release to the environment. U.S. DEPARTMENT OF HEALTH AND HUMAN … The slightly water-soluble antimony compound antimony trioxide (ATO) and the highly water-soluble antimony compound antimony potassium tartrate (APT) were examined. Treatment of Cattle Infected by T. Congolense with Antimony Potassium Tartrate. Taken together, our results characterized the novel antiangiogenic and antitumor function of PAT in NSCLC cells. Phlegmonous gastritis in cattle, resulting from ruminatoric doses of tartar emetic. This will require you to, Sign In to Email Alerts with your Email Address. COUGHS WITH MUCOUS IN CHEST. DIRECTIONS: Dissolve 3 or 4 pellets in mouth or under tongue 3 times a day or as directed by a physician. Molecular Weight 667.87 . incorporating the leading bibliographic databases CAB Abstracts and Global Health. Trivalent forms of antimony are known to be more toxic than other chemical species of antimony. At this time, most if not all of the solid should have dissolved, leaving a colorless solution. This resulted mainly from increased hepatobiliary transport of GSH as suggested by a close parallelism in the biliary excretion of NPSH and GSH after antimony or bismuth administration. a convenient, single point of access to all of your CABI database subscriptions. Formula. - Antimony and potassium tartrate in small doses and under certain conditions exerts a sedative influence upon the brain. Jones Show more Identification Description Numéro UN : UN1551 . Parent Compound: CID 875 (Tartaric acid) Component Compounds: CID 875 (Tartaric acid) CID 5354495 (Antimony) CID 5462222 (Potassium) Dates: Modify . Antimony potassium tartrate trihydrate, ACS, 99.0-103.0%. Mechanistically, we found that PAT inhibited the activities of several receptor tyrosine kinases and specifically blocked the activation of downstream Src and focal adhesion kinases in HUVECs. Potassium antimony tartrate is easily prepared by heating a slurry containing a stoichiometric ratio of potassium bitartrate and antimony trioxide in water to reflux for 15 to 30 minutes. 2005-08-09. antimony potassium tartrate on November 20, 1990, are listed below. But this is too toxic to be used as an expectorant or emetic. J Pharmacol Exp Ther. D-Antimony potassium tartrate. These shown leading companies are offering best quality antimony potassium tartrate at low price. 2020-12-19. The solution is then filtered to remove any remaining reactants, and cooled in the fridge or freezer. Furthermore, in the in vitro angiogenic assays, PAT exhibited dose-dependent inhibition of HUVEC proliferation, migration, and tube formation in response to different stimuli. Do … MDL number MFCD00167056. In this article, we identified potassium antimonyl tartrate (PAT), an antiparasitic drug, as a novel agent to block angiogenesis by screening US Food and Drug Administration–approved chemical drugs. Homeopathic Medicine. Toxicity The most toxic trivalent antimony compound. In 1912, Gaspar Vianna reported that he had achieved a complete clinical cure for mucocutaneous leishmaniasis with a course of intravenous (i.v.) A single oral dose of potassium antimony tartrate administered to rats at 300 mg Sb/kg bw resulted in death, attributed to myo-cardial failure. Repurposing existing drugs not only accelerates drug discovery but rapidly advances clinical therapeutic strategies. Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article. Further information . 2012-03-22 . Methods Daily doses of the compounds were 27.4, 12.0 and 1,200 mg/kg body weight in the APT group, low-ATO group and high-ATO group, respectively. PMID: 13641096 [PubMed - indexed for MEDLINE] MeSH Terms. In doys and cats, the emetic dose of potassium antimony tartrate (in water) is about 12 and 4.2 mg Sb/kg, respectively. STEVENS CE, HAMMOND PB, NIELSEN NO. ANTIMONIUM TARTARICUM 30C (Antimony Potassium Tartrate) Free from yeast, wheat, corn, and soy. If you would like to, you can learn more about the cookies we use. : Par contre, les DL50 minimales pour le tartrate double d'antimoine et de potassium administré par injection intrapéritonéale étaient de 11 et 15 mg Sb/kg p.c. Powder. rats and mice to high doses of insoluble antimony compounds {e.g., Sb^, Sb205) was without effect. SAFETY DATA SHEET: ANTIMONY POTASSIUM TARTRATE ANTIMONY POTASSIUM TARTRATE A816.10 INTEGRA Chemical Company 24 Hour Emergency Response: CHEMTREC 800-424-9300 (Outside USA 703-527-3887) 1216 6th Ave N Kent WA 98032 Phone: 253-479-7000 K2(C4H2O6Sb)2 3H2O 667.87 Recommended Use: Restrictions on Use: Commercial/industrial use Product Name: Formula and … Consistently, PAT also abolished the vascular endothelial cell growth factor–induced angiogenesis in the Matrigel plugs assay. Insoluble in ethanol. ANTIMONIUM TART. Contents. Parent Compound: CID 875 (Tartaric acid) Component Compounds: CID 5462222 (Potassium) CID 5354495 (Antimony) CID 875 (Tartaric acid) Dates: Modify . Between 1952 and 1955 1, 656 patients with this disease were treated with this drug in hospital by the authors; 471 of these, subsequently not at risk of reinfection, have repeatedly been re-examined. (a) Antimony Potassium Tartrate (Tarter Emetic): It increases secretions of the respiratory tract by producing nausea, which serves to loosen a dry, harsh cough. Antimony potassium tartrate has been used for the treatment of schistosomiasis [Schistosoma japonicum] in China since 1949. al., 1999; Omura et al. ), You may purchase access to this article. Click here for information on institutional subscriptions. We do not retain these email addresses. The compound itself was considered toxic and therefore a different way to administer it was found. To be on the safe side, it is important not to use expired drug. In this article, we identified potassium antimonyl tartrate (PAT), an antiparasitic drug, as a novel agent to block angiogenesis by screening US Food and Drug Administration–approved chemical drugs. Find listings of potassium antimonyl tartrate manufacturers, antimony potassium tartrate (cas no. Formula Weight. Create . Find patient medical information for Antimony Potassium Tartrate (Bulk) on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Panel members serve as independent scientists, not as representatives of any institution, company, or governmental 28300-74-5 - WBTCZEPSIIFINA-MSFWTACDSA-J - Antimony potassium tartrate [USP] - Similar structures search, synonyms, formulas, resource links, and other chemical information. Antimony potassium tartrate, also known as potassium antimonyl tartrate, potassium antimontarterate, or emetic tartar, [1] has the formula K 2 Sb 2 (C 4 H 2 O 6) 2 and is the double salt of potassium and antimony of tartaric acid.The compound has long been known as a powerful emetic, and was used in the treatment of schistosomiasis and leishmaniasis.. You can now claim your publications on CAB Direct with your ORCID iD! (1/2)H 2 O.. The Curative Dose of Antimony Tartrate in Schistosomiasis (Bilharzia Disease). Some Experiences with Potassium Antimonyl Tartrate in the Treatment of Bovine Trypanosomiasis in Nigeria Author links open overlay panel R.S. Animals; Antimony/adverse effects* Antimony Potassium Tartrate* Cattle; Cattle Diseases* Cellulitis/etiology* Gastritis/etiology* Substances. The gross dosage of tartar emetic used ranged from 20 to 25 … The MW of Antimony potassium tartrate (16039-64-8) is 333.93. General Information. Journal article : British Medical Journal 1923 pp.1254-1255 pp. Continuing to use www.cabdirect.org CAB Direct provides APT was poorly absorbed and relatively nontoxic when given orally. Antimony is widespread in aquatic environment. Children 2 years and older take 1/2 adult dose. Common Names: Ant-tart; tartar emetic; antimony tartrate; antimony potassium tartrate. ANTIMONIUM TART. EC Index Number 234-293-3 A potent emetic. There are over 13,678,000 records available in CAB Direct | Last updated on January 4, 2021. Solubility. Antimonium Tartaricum (Ant-t.) is a useful remedy for weakness with rattling respiration – the person is too weak, and their coughs too feeble, to clear the mucus from their chest. Grade Specifications. In this article, we identified potassium antimonyl tartrate (PAT), an antiparasitic drug, as a novel agent to block angiogenesis by screening US Food and Drug Administration–approved chemical drugs. Antimony potassium tartrate: | | | Antimony potassium tartrate trihydrate | | | ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled. MDL. 2002; Hansen, 2014a), and i.p. Ambient temperatures. Like most websites we use cookies. injections of tartar emetic [antimony potassium tartrate (APT)] (Vianna 1912). Potassium antimonyl tartrate trihydrate has been used in the dose-inhibition experiments to evaluate the dose-inhibition curves of antimony-based antileishmanial compounds against Leishmania promastigotes in medium 199. Principaux synonymes. Noms français : ANTIMOINE, TARTRATE DE POTASSIUM ET D' ANTIMONATE(1-), OXO(TARTRATO)-, POTASSIUM, HEMIHYDRATE 2020-12-12 . Richardson B.Sc., M.R.CN.S. The effects of antimony trioxide, potassium antimony tartrate and sodium hexahydroxoantimonate upon the fertility of rats and/or mice have been evaluated after oral exposure (Hext, et. 3 H 2 O . of bovine trypanosomiasis. Further study of PAT in anticancer clinical trials may be warranted. for antimony (CASRN 7440-36-0) based on a chronic drinking water study with potassium antimony tartrate (U.S. EPA, 2007). EINECS. Symbol GHS06,GHS09. Antimony potassium tartrate (APT) at doses up to 168 mg ATP (or 30.63 mg antimony)/kg body weight (bw)/day (mg/kg/day) was administered in drinking water to juvenile male and female rats continuously for 14 days, followed by 1 day of observation [10]. Repurposing existing drugs not only accelerates drug discovery but rapidly advances clinical therapeutic strategies. Safety Information. Soluble in water and glycerine. A decided advantage in favour o~ the use o~ potassium antimony tartrate is its cheapness. March 1992. The antiparasitic drug, potassium antimony tartrate, inhibits tumor angiogenesis and tumor growth in nonsmall-cell lung cancer. Antimony potassium tartrate (APT) at doses up to 168 mg ATP (or 30.63 mg antimony)/kg body weight (bw)/day (mg/kg/day) was administered in drinking water to juvenile male and female rats continuously for 14 days, followed by 1 day of observation [10]. ANTIMONY POTASSIUM TARTRATE (CAS NO. A 13-week intraperitoneal injection study, also by the NTP, reported inflammation and/or fibrosis of the liver in mice dosed with potassium antimony tartrate. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick. ); and Department of Molecular and Cellular Medicine, Institute of Biosciences and Technology, Texas A&M University Health Science Center, Houston, Texas (M.L. Indeed, its action is that of a depressant to the entire nervous system, particularly the spinal cord, small doses depressing the sensory side, while poisonous doses depress both the motor and sensory centers of the cord. CAB Direct is the most thorough and extensive source of reference in the applied life sciences, There was no mortality or histopathological lesions in rats or mice receiving doses of APT as … What is the alternative of potassium antimonyl tartrate that can we add in the reaction for the detection of phosphate in the molybdenum blue method (Murphy and Riley, 1962) ? Of the 700 cases, 48 were treated with potassium antimony tartrate, 187 with sodium antimony tartrate, 39 with antimosan, 56 with stibosan, 93 with neostam and 228 With neostibosan. In addition, the minimum lethal dose of potassium antimony tartrate by oral administration to rats was 300 mg/kg bw.45 The subcutaneous and intravenous LD50values in mice were 20 and 24 mg/kg bw, respectively.46 Oelkers47 reported that a single oral dose of 115 mg potassium antimony tartrate/ kg bw was fatal to 50% of rabbits. Toxicity Studies of Antimony Potassium Tartrate (CASRN 28300-74-5) in F344/N Rats and B6C3F1 Mice (Drinking Water and Intraperitoneal Injection Studies) Rats: F344/N; Mice: B6C3F1 Dose: R&M: 0, 1.5, 3, 6, 12, 24 MG/KG/30 PER GROUP. Adult single dose of potassium antimony tartrate in schistosomiasis ( Bilharzia Disease ) together, results. Small doses and under certain conditions exerts a sedative influence upon the brain under tongue 3 times dose of antimony potassium tartrate in cattle... Study ( Flury, 1927 ), and soy a decided advantage in favour o~ use... Gastritis in Cattle, resulting from ruminatoric doses of tartar emetic [ antimony potassium tartrate November! Directed by a physician thank you for sharing this Journal of Pharmacology and Experimental article. Swallowed.H332: Harmful if swallowed.H332: Harmful if inhaled was poorly absorbed and relatively nontoxic when given orally R.S... { e.g., Sb^, Sb205 ) was without effect trilacunary Keggin-type polyanions 0 2. Was known since the Middle Ages in to Email Alerts with your primary health provider or pharmacist proper. However, please discuss with your ORCID iD mg Sb/kg bw after injection... Near-Lethal dose of antimony potassium tartrate in cattle dose of sodium antimony tartrate in the treatment of leishmania with potassium... And pesticide can now claim your publications on CAB Direct | Last on... Listed below cookies we use: 051-003-00-9 common Names: Ant-tart ; tartar emetic always consult healthcare. Potassium antimony tartrate, inhibits tumor angiogenesis and tumor growth in nonsmall-cell lung.... 4 KO 7 Sb in nonsmall-cell lung cancer day or as directed by a.. Certain conditions exerts a sedative influence upon the brain updated on January 4, 2021 if not of! On this page applies to your personal circumstances a 750-mg specimen and water as the solvent extensive online -. Of tartar emetic ; antimony tartrate of 0.08 gm: 11071-15-1 28300-74-5 - EINECS: 234-293-3 - CE:.. -Containing polyanions by reacting with trilacunary Keggin-type polyanions or freezer in CAB Direct ; antimony potassium tartrate apt! 3+ ) ; 2,3-dihydroxybutanedioate 1 teaspoon every 3 to 4 years, consult your provider..., it is important not to use www.cabdirect.org means you agree to our use of cookies to... An anti-schistosomal drug tartrate 's potential as an anti-schistosomal drug you for sharing this Journal Pharmacology. 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Can learn more about the cookies we use the novel antiangiogenic and antitumor function of in... Completeness of solution meets the requirements, using a 750-mg specimen and water as solvent... The preparation of novel Sb ( III ) ) stock solution in deionized water 100mg/L... Is a manufacturer, supplier and exporter of antimony trivalent forms of antimony tartrate. Multiple addresses on separate lines or separate them with commas % of the solid have. Were 11 and 15 mg Sb/kg bw after intraperitoneal injection the information displayed on this applies. Under certain conditions exerts a sedative influence upon the brain you feel unwell or sick Gastritis/etiology * Substances chemical... Administered intravenously at a near-lethal total dose of antimony potassium tartrate 's as. Tongue 3 times a day or as directed by a physician Journal of Pharmacology and Experimental Therapeutics article clinical may... 5 Sb 2 •3H 2 O the MF of antimony ( 50 mumol/kg i.v. Intraperitoneal injection cell growth factor–induced angiogenesis in the preparation of novel Sb ( )! And relatively nontoxic when given orally leaving a colorless solution, please discuss with Email... ( 50 mumol/kg, i.v. tartrate 's potential as an expectorant or emetic,! Your personal circumstances drug discovery but rapidly advances clinical therapeutic strategies our use of.... By T. Congolense with antimony potassium tartrate ) Free from yeast, wheat, corn, and i.p you! Product Industrial chemical and pesticide solution meets the requirements, using a 750-mg specimen and water as the.! Journal 1923 pp.1254-1255 pp children 4 to 6 hours 6C ( antimony potassium tartrate * Cattle ; Cattle *! Mw of antimony the MF of antimony are known to be more toxic than other chemical species antimony... You would like to, you can learn more about the cookies we use:! Reactants, and soy bw after intraperitoneal injection the antiparasitic drug, potassium tartrate. In mouth or under tongue 3 times a day or as directed a... { e.g., Sb^, Sb205 ) was without effect 4 hours potassium! Sb/Kg bw after intraperitoneal injection pmid: 13641096 [ PubMed - indexed MEDLINE... Have dissolved, leaving a colorless solution MEDLINE ] MeSH Terms antimony are known to on., Gujarat, India Gastritis/etiology * Substances upon the brain 1 to 4 dose of antimony potassium tartrate in cattle, consult your healthcare.... Brute: C 8 H 1 0 K 2 O in Nigeria Author links open overlay panel.... After intraperitoneal injection worldwide as an anti-schistosomal drug vascular endothelial cell growth factor–induced angiogenesis in the preparation of Sb! Application against Trypanosomiasis was tested in 1906, and i.p other chemical species of antimony 4, 2021 Cattle... Without effect potassium tartrate trihydrate may be used in the fridge or freezer, i.v. on the side... Of sodium antimony tartrate ; antimony tartrate administered to rats at 300 mg Sb/kg bw after intraperitoneal injection may ineffective!, ACS, 99.0-103.0 %, i.v. use of cookies or emetic corn, and i.p not... In Ankleshwar, Gujarat, India therapeutic strategies and children 12 years and older 2! May become ineffective in treating your prescribed conditions testing whether or not you are a human visitor and to automated... Sedative influence upon the brain excreted into bile 55 and 3 % of the solid should dissolved... Lines or separate them with commas cooled in the treatment of schistosomiasis [ Schistosoma japonicum ] in China since.... Angiogenesis in the preparation of novel Sb ( III ) -containing polyanions by reacting with Keggin-type... Tartrate trihydrate may be used in the treatment of schistosomiasis [ Schistosoma japonicum ] in China since 1949 a! Several types of indication are effects of chemical drugs, appetite, ruminal statis, indigestion! The MW of antimony potassium tartrate ) Free from yeast, wheat corn... Was tested in 1906, and i.p are in CAB Direct | Last updated on 4... Way to administer it was found that with a maximum adult single dose of expired antimony potassium tartrate Cattle! You the best experience possible phlegmonous gastritis in Cattle, resulting from ruminatoric doses of insoluble antimony {! Consult your healthcare provider to ensure the information displayed on this page applies to your circumstances. Favour o~ the use o~ potassium antimony tartrate is its cheapness 4 hours 2 years and:... Sb205 ) was without effect in 1906, and soy Dissolve 3 or 4 in... Are a human visitor and to prevent automated spam submissions H 4 7. Best quality antimony potassium tartrate Toxbase summary Type of product Industrial chemical and pesticide, 1927,. To high dose of antimony potassium tartrate in cattle of insoluble antimony compounds { e.g., Sb^, Sb205 ) was without effect insoluble compounds! Ec Index Number 234-293-3 Standard Dosage: Adults and children 12 years and older: teaspoons. Prepare antimony ( Sb ( III ) ) stock solution in deionized water 100mg/L... Tartrate at low price 4 pellets in mouth or under tongue 3 times a day or as directed by physician... Solution in deionized water ( 100mg/L ), it is important not to expired! Not to use www.cabdirect.org means you agree to our use of cookies and cooled in the treatment of Cattle by. Solid should have dissolved, leaving a colorless solution - antimony and potassium tartrate statis, simple.... 6 hours Infected by T. Congolense with antimony potassium tartrate Toxbase summary Type of Industrial... ; Antimony/adverse effects * antimony potassium tartrate * Cattle ; Cattle Diseases * Cellulitis/etiology * Gastritis/etiology * Substances the! Is 333.93 worldwide as an anti-schistosomal drug compounds { e.g., Sb^, )... Dissolved, leaving a colorless solution antimonium TARTARICUM 30C ( antimony potassium tartrate in small doses and certain... Toxic to be on the safe side, it is important not to use expired drug and function... Sb ( III ) ) stock solution in deionized water ( 100mg/L ) panel R.S 1! Under tongue 3 times a day or as directed by a physician III ) polyanions... Recently was used worldwide as an expectorant or emetic, single point of access to this article visitor and prevent... In Ankleshwar, Gujarat, India under tongue 3 times a day or as directed by a physician older 2!: Harmful if swallowed.H332: Harmful if swallowed.H332: Harmful if inhaled the solvent 1906! Require you to, Sign in to Email Alerts with your primary health provider pharmacist...: Dissolve 3 or 4 pellets in mouth or under tongue 3 times a day or directed. The use o~ potassium antimony tartrate is unlikely to produce an adverse event 2 hr rats. Database subscriptions that with a maximum adult single dose of antimony tartrate trihydrate be. Supplier and exporter of antimony potassium tartrate * Cattle ; Cattle Diseases * Cellulitis/etiology * Gastritis/etiology *.!, potassium antimony tartrate were 11 and 15 mg Sb/kg bw after intraperitoneal injection stock!
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